Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6662176 | 0.83 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL8539769 | 0.79 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL15651765 | 0.78 | TSHR (0.68) | ALDH1A1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL10157035 | 0.78 | TSHR (0.56) | ALDH1A1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL11689995 | 0.76 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL11410309 | 0.75 | KMT2A (0.59) | ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL8542275 | 0.75 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL7243296 | 0.74 | PKM (0.75) | ALDH1A1TSHRKDM4EPKMPOLB | |
| SCHEMBL1143451 | 0.74 | POLB (0.72) | ALDH1A1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL9400292 | 0.74 | ALDH1A1 (0.70) | ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0584085-B1 | ANTIBIOTIC CARBAPENEM DERIVATIVES | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5554606-A | THIENAMYCIN DERIVATIVES; PSEUDOMONAS | ZENECA LIMITED (GB) | 1996-09-10 | — | — | US | disclosed |
| EP-0584085-A1 | ANTIBIOTIC CARBAPENEM DERIVATIVES | ZENECA LIMITED (GB) | 1994-03-02 | — | — | EP | disclosed |
| WO-1992017479-A1 | ANTIBIOTIC CARBAPENEM DERIVATIVES | ZENECA LTD. (GB) | 1992-10-15 | — | — | WO | disclosed |