Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | CD4 | P01730 | 2/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540877 | 1.00 | HTR6 (0.54) | HTR6SMN1; SMN2BCHELMNAALDH1A1 | |
| SCHEMBL1943416 | 0.93 | ACHE (0.53) | HTR6SMN1; SMN2BCHEACHECD4 | |
| SCHEMBL14166152 | 0.93 | SMN1; SMN2 (0.56) | HTR6SMN1; SMN2LMNAALDH1A1TSHR | |
| SCHEMBL9212450 | 0.92 | BCHE (0.50) | HTR6SMN1; SMN2BCHELMNAALDH1A1 | |
| SCHEMBL9217317 | 0.91 | HTR2A (0.55) | HTR6BCHEALDH1A1ACHEDRD2 | |
| SCHEMBL19475540 | 0.88 | SMN1; SMN2 (0.55) | HTR6SMN1; SMN2LMNAALDH1A1TSHR | |
| SCHEMBL7782471 | 0.88 | HTR6 (0.53) | HTR6SMN1; SMN2BCHELMNAALDH1A1 | |
| SCHEMBL1474769 | 0.84 | SMN1; SMN2 (0.48) | HTR6SMN1; SMN2BCHELMNAALDH1A1 | |
| SCHEMBL1474768 | 0.84 | SMN1; SMN2 (0.48) | HTR6SMN1; SMN2BCHELMNAALDH1A1 | |
| SCHEMBL1474765 | 0.84 | SMN1; SMN2 (0.48) | HTR6SMN1; SMN2BCHELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116504-A2 | RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTOR MODULATORS AND USES THEREOF | Innov17 LLC (US) | 2017-01-18 | — | — | EP | disclosed |
| WO-2015138276-A2 | RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTOR MODULATORS AND USES THEREOF | INNOV17 LLC (US) | 2015-09-17 | — | — | WO | disclosed |
| US-5770611-A | Indole derivatives as 5HT1 -like agonists | PFIZER INC. (US) | 1998-06-23 | — | — | US | disclosed |
| EP-0785933-B1 | INDOLE DERIVATIVES AS 5HT1-LIKE AGONISTS | PFIZER LTD (GB) | 1998-03-11 | — | — | EP | disclosed |