Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 5/20 | 0.50 |
| ▸ | ACHE | P22303 | 5/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | CD4 | P01730 | 2/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.44 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.44 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1943416 | 0.97 | ACHE (0.53) | BCHEACHEMAOBOPRM1OPRK1 | |
| SCHEMBL8540877 | 0.92 | HTR6 (0.54) | BCHEACHEOPRM1OPRK1CD4 | |
| SCHEMBL8540875 | 0.92 | HTR6 (0.54) | BCHEACHEOPRM1OPRK1CD4 | |
| SCHEMBL9208266 | 0.88 | BCHE (0.58) | BCHEACHEMAOBHTR6MAOA | |
| SCHEMBL19475540 | 0.88 | SMN1; SMN2 (0.55) | ACHECD4SORT1HTR6SMN1; SMN2 | |
| SCHEMBL14166152 | 0.85 | SMN1; SMN2 (0.56) | ACHECD4SORT1HTR6SMN1; SMN2 | |
| SCHEMBL8088969 | 0.83 | DRD2 (0.42) | BCHEACHEOPRM1OPRK1MEN1 | |
| SCHEMBL8088966 | 0.83 | DRD2 (0.42) | BCHEACHEOPRM1OPRK1MEN1 | |
| SCHEMBL9217317 | 0.83 | HTR2A (0.55) | BCHEACHEMAOBHTR6ALDH1A1 | |
| SCHEMBL12090230 | 0.81 | BCHE (0.58) | BCHEACHEMAOBMAOAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |