Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4263745 | 0.89 | DRD2 (0.64) | DRD2DRD3DRD1OPRK1MAPT | |
| Bromide SCHEMBL7200937 | 0.88 | DRD2 (0.62) | DRD2DRD3DRD1OPRK1MAPT | |
| SCHEMBL8542055 | 0.80 | FYN (0.50) | DRD2DRD3DRD1OPRK1NFKB1 | |
| SCHEMBL10881441 | 0.76 | DRD2 (0.56) | DRD2DRD3OPRK1MAPTNFKB1 | |
| SCHEMBL3797823 | 0.73 | BCL2L1 (0.56) | DRD2DRD1 | |
| SCHEMBL1535927 | 0.73 | BCL2L1 (0.50) | DRD2DRD1 | |
| SCHEMBL8411065 | 0.73 | ADRA2A (0.51) | ADRA1A | |
| SCHEMBL8548253 | 0.71 | MTNR1A (0.51) | DRD2DRD1 | |
| SCHEMBL8765153 | 0.70 | DRD2 (0.80) | DRD2DRD3OPRK1MAPTNFKB1 | |
| SCHEMBL8765149 | 0.70 | DRD2 (0.80) | DRD2DRD3OPRK1MAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608568-B1 | Aminocycloalkanobenzodioxoles as beta-3 selective adrenergic agents | AMERICAN CYANAMID CO (US) | 1998-03-11 | — | — | EP | disclosed |
| US-5510376-A | TREATING DIABETES, HYPERGLYCEMIA, OBESITY | AMERICAN CYANAMID COMPANY (US) | 1996-04-23 | — | — | US | disclosed |
| EP-0608568-A1 | Aminocycloalkanobenzodioxoles as beta-3 selective adrenergic agents | AMERICAN CYANAMID COMPANY (US) | 1994-08-03 | — | — | EP | disclosed |