Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP11 | Q9NR21 | 8/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 8/20 | 0.51 |
| ▸ | GRM5 | P41594 | 5/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21040262 | 0.82 | PARP11 (0.55) | PARP11PARP10GRM5GABRG2GABRB3 | |
| SCHEMBL30527041 | 0.82 | PARP11 (0.55) | PARP11PARP10GRM5GABRG2GABRB3 | |
| SCHEMBL8323443 | 0.80 | GRM5 (0.67) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL379341 | 0.80 | GRM5 (0.67) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL19574541 | 0.80 | PARP11 (0.55) | PARP11PARP10GRM5GABRG2GABRB3 | |
| SCHEMBL1036450 | 0.77 | KCNA5 (0.53) | PARP11PARP10GRM5GABRG2GABRB3 | |
| SCHEMBL25597402 | 0.76 | PARP11 (0.50) | PARP11PARP10GRM5GABRG2GABRB3 | |
| SCHEMBL8545541 | 0.76 | ADRA2A (0.59) | PARP11PARP10GRM5GABRG2GABRB3 | |
| Hydrochloric Acid SCHEMBL12502617 | 0.76 | PARP11 (0.50) | PARP11PARP10GRM5GABRG2GABRB3 | |
| SCHEMBL1239440 | 0.76 | PARP11 (0.50) | PARP11PARP10GRM5GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526402-B1 | Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitors | CIBA GEIGY AG (CH) | 1998-01-21 | — | — | EP | disclosed |
| US-5350761-A | Lipoxygenase inhibitors as antiinflammatory agents and antiallergens | CIBA-GEIGY CORPORATION (US) | 1994-09-27 | — | — | US | disclosed |
| US-5334600-A | Lipoxygenase inhibitors | CIBA-GEIGY CORPORATION (US) | 1994-08-02 | — | — | US | disclosed |
| US-5260316-A | Lipoxygenase inhibitor | CIBA-GEIGY CORPORATION (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0526402-A1 | Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitors | CIBA-GEIGY AG (CH) | 1993-02-03 | — | — | EP | disclosed |