SCHEMBL8543015

SCHEMBL8543015

NCCc1c[nH]c2ccc(OCc3ccccc3)c(Cl)c12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 4/20 0.56
KDM4E B2RXH2 1/20 0.56
MAPT P10636 1/20 0.56
LTA4H P09960 5/20 0.55
PLA2G2A P14555 5/20 0.55
HTR2A P28223 6/20 0.51
HTR1D P28221 4/20 0.47
HTR1B P28222 4/20 0.47
HTR1A P08908 3/20 0.47
HTR2C P28335 2/20 0.44
MPO P05164 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2A6 P11509 1/20 0.41
NFKB1 P19838 1/20 0.41
HTR7 P34969 1/20 0.41
CTSK P43235 1/20 0.41
HTR6 P50406 1/20 0.41
CYP2A13 Q16696 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8547802 0.99 LTA4H (0.57) TRPM8KDM4EMAPTLTA4HPLA2G2A
SCHEMBL8544006 0.84 HTR2A (0.73) TRPM8HTR2AHTR1DHTR1BHTR1A
Hydrochloric Acid SCHEMBL8549336 0.83 HTR2A (0.71) TRPM8LTA4HPLA2G2AHTR2AHTR1D
SCHEMBL23805211 0.83 HTR2A (0.71) TRPM8KDM4EMAPTLTA4HPLA2G2A
Hydrochloric Acid SCHEMBL274592 0.82 HTR2A (0.70) TRPM8KDM4EMAPTLTA4HPLA2G2A
SCHEMBL8545281 0.81 HTR2A (0.56) TRPM8KDM4EMAPTLTA4HPLA2G2A
SCHEMBL8549558 0.81 HTR2A (0.45) TRPM8KDM4EMAPTLTA4HPLA2G2A
Fumaric Acid SCHEMBL9075793 0.80 HTR2A (0.52) TRPM8KDM4EMAPTLTA4HPLA2G2A
Fumaric Acid SCHEMBL9075796 0.80 HTR2A (0.52) TRPM8KDM4EMAPTLTA4HPLA2G2A
SCHEMBL8543442 0.80 HTR1A (0.54) TRPM8KDM4EMAPTHTR2AHTR1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP claimed
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP disclosed
US-5571833-A TREATMENT OF MIGRAINE, PORTAL HYPERTENSION SMITHKLINE BEECHAM PLC (GB) 1996-11-05 US disclosed
EP-0593513-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1994-04-27 EP disclosed
WO-1993000333-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-01-07 WO disclosed