SCHEMBL8544006

SCHEMBL8544006

CN(C)CCc1c[nH]c2ccc(OCc3ccccc3)c(Cl)c12

nearest known ligand 0.73

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 8/20 0.73
HTR1D P28221 5/20 0.58
TRPM8 Q7Z2W7 1/20 0.58
HTR1A P08908 6/20 0.52
HTR6 P50406 2/20 0.51
SLC6A4 P31645 3/20 0.51
HTR2C P28335 5/20 0.47
HTR2B P41595 4/20 0.47
HTR1B P28222 2/20 0.47
DRD1 P21728 1/20 0.47
HTR1E P28566 1/20 0.47
ADORA2A P29274 1/20 0.47
ADORA2B P29275 1/20 0.47
HTR7 P34969 1/20 0.47
DRD3 P35462 1/20 0.47
HTR5A P47898 1/20 0.47
SLC6A2 P23975 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8549336 0.99 HTR2A (0.71) HTR2AHTR1DTRPM8HTR1AHTR6
SCHEMBL8545281 0.88 HTR2A (0.56) HTR2AHTR1DTRPM8HTR1AHTR6
SCHEMBL25281662 0.87 HTR2A (0.74) HTR2AHTR1DTRPM8HTR1AHTR6
SCHEMBL8543015 0.84 TRPM8 (0.56) HTR2AHTR1DTRPM8HTR1AHTR6
SCHEMBL12558834 0.84 HTR2A (1.00) HTR2AHTR1DTRPM8HTR1AHTR6
SCHEMBL29511892 0.84 HTR2A (1.00) HTR2AHTR1DTRPM8HTR1AHTR6
SCHEMBL8868776 0.83 HTR1A (0.54) HTR2AHTR1DTRPM8HTR1AHTR6
Hydrochloric Acid SCHEMBL8547802 0.83 LTA4H (0.57) HTR2AHTR1DTRPM8HTR1AHTR2C
Fumaric Acid SCHEMBL9075796 0.83 HTR2A (0.52) HTR2AHTR1DTRPM8HTR1AHTR6
Fumaric Acid SCHEMBL9075793 0.83 HTR2A (0.52) HTR2AHTR1DTRPM8HTR1AHTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP claimed
US-5571833-A TREATMENT OF MIGRAINE, PORTAL HYPERTENSION SMITHKLINE BEECHAM PLC (GB) 1996-11-05 US claimed
EP-0593513-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1994-04-27 EP claimed
WO-1993000333-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-01-07 WO claimed
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP disclosed
US-5571833-A TREATMENT OF MIGRAINE, PORTAL HYPERTENSION SMITHKLINE BEECHAM PLC (GB) 1996-11-05 US disclosed
EP-0593513-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1994-04-27 EP disclosed
WO-1993000333-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-01-07 WO disclosed