SCHEMBL8545281

SCHEMBL8545281

CN(C)Cc1c[nH]c2ccc(OCc3ccccc3)c(Cl)c12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 4/20 0.56
HTR1D P28221 3/20 0.46
TRPM8 Q7Z2W7 2/20 0.46
HTR2C P28335 1/20 0.45
HTR2B P41595 1/20 0.45
SLC6A4 P31645 1/20 0.45
CCR5 P51681 2/20 0.43
KDM4E B2RXH2 2/20 0.43
MEN1 O00255 1/20 0.43
ALDH1A1 P00352 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
TSHR P16473 1/20 0.43
CYP2C19 P33261 1/20 0.43
KMT2A Q03164 1/20 0.43
HSD17B10 Q99714 1/20 0.43
MAPT P10636 1/20 0.39
LMNA P02545 1/20 0.39
GAA P10253 1/20 0.39
LTA4H P09960 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8544006 0.88 HTR2A (0.73) HTR2AHTR1DTRPM8HTR2CHTR2B
Hydrochloric Acid SCHEMBL8549336 0.87 HTR2A (0.71) HTR2AHTR1DTRPM8HTR2CHTR2B
SCHEMBL7366247 0.84 HTR2A (0.77) HTR2AHTR1DTRPM8HTR2CHTR2B
SCHEMBL8869200 0.82 SLC6A4 (0.51) HTR2AHTR2CHTR2BSLC6A4KDM4E
SCHEMBL8543015 0.81 TRPM8 (0.56) HTR2AHTR1DTRPM8HTR2CKDM4E
SCHEMBL8549160 0.81 HTR2A (0.45) HTR2AHTR1DHTR2CHTR2BSLC6A4
SCHEMBL8549558 0.81 HTR2A (0.45) HTR2AHTR1DTRPM8SLC6A4KDM4E
Hydrochloric Acid SCHEMBL8547802 0.81 LTA4H (0.57) HTR2AHTR1DTRPM8HTR2CKDM4E
SCHEMBL8546408 0.80 HTR1A (0.52) HTR2AHTR1DHTR2CHTR2BSLC6A4
SCHEMBL8549767 0.80 HTR2A (0.44) HTR2AHTR1DHTR2CHTR2BSLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP disclosed
US-5571833-A TREATMENT OF MIGRAINE, PORTAL HYPERTENSION SMITHKLINE BEECHAM PLC (GB) 1996-11-05 US disclosed
EP-0593513-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1994-04-27 EP disclosed
WO-1993000333-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-01-07 WO disclosed