Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546135 | 0.98 | ACHE (0.47) | ACHEEPHX2HRH3 | |
| SCHEMBL8544785 | 0.97 | ACHE (0.46) | ACHEEPHX2HRH3 | |
| SCHEMBL8539650 | 0.95 | ACHE (0.46) | ACHEEPHX2HRH3CYP2C9CYP2C19 | |
| SCHEMBL8544287 | 0.83 | HRH3 (0.45) | ACHEHRH3 | |
| SCHEMBL8542776 | 0.82 | ACHE (0.58) | ACHE | |
| SCHEMBL8539614 | 0.81 | ACHE (0.52) | ACHEHRH3 | |
| SCHEMBL8544556 | 0.80 | MEN1 (0.43) | ACHECYP2C9CYP2C19 | |
| SCHEMBL9316755 | 0.80 | OPRM1 (0.52) | ACHE | |
| SCHEMBL8539296 | 0.79 | ACHE (0.50) | ACHE | |
| SCHEMBL8539445 | 0.78 | THRB (0.53) | HRH3CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0671388-B1 | (Pyrrolidinyl)phenyl carbamates and intermediate compounds, processes for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-06-10 | — | — | EP | disclosed |
| US-5591856-A | CHEMICAL INTERMEDIATES, TREATMENT OF ALZHEIMER'S DISEASE | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1997-01-07 | — | — | US | disclosed |
| US-5554750-A | TO RELIEVE MEMORY DYSFUNCTIONS; TREATMENT OF ALZHEMER*S | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-09-10 | — | — | US | disclosed |
| EP-0671388-A1 | (Pyrrolidinyl)phenyl carbamates and intermediate compounds, processes for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1995-09-13 | — | — | EP | disclosed |
| US-5405845-A | Administering to relieve memory dysfunction; treatment of Alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-04-11 | — | — | US | disclosed |
| US-5338739-A | Memory dysfunction relieving compounds | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-08-16 | — | — | US | disclosed |