Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | HTR2C | P28335 | 5/20 | 0.46 |
| ▸ | HTR2B | P41595 | 5/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871368 | 0.83 | PRCP (0.42) | HTR2AHTR2CHTR2BHRH3JAK2 | |
| SCHEMBL4001774 | 0.82 | MEN1 (0.52) | KDM4EMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL6587573 | 0.82 | SLC6A3 (0.48) | HTR2AHTR2CHTR2BHRH3SLC6A2 | |
| SCHEMBL8485182 | 0.82 | DRD2 (0.41) | HTR2AHTR2CHTR2BL3MBTL1MEN1 | |
| SCHEMBL21856329 | 0.81 | HTR2C (0.48) | HTR2AHTR2CHTR2BHRH3 | |
| Hydrochloric Acid SCHEMBL11553849 | 0.80 | MEN1 (0.50) | KDM4EMEN1KMT2AMAPK1CYP3A4 | |
| SCHEMBL8540341 | 0.80 | SLC6A2 (0.42) | PKMCYP19A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21958808 | 0.79 | HTR2C (0.41) | HTR2AHTR2CHTR2BHRH3 | |
| SCHEMBL8130957 | 0.78 | GID4 (0.53) | HTR2AHTR2CHTR2BCYP19A1KDM4E | |
| Formamide SCHEMBL11551135 | 0.73 | MEN1 (0.44) | SLC6A3MEN1KMT2ACYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721949-B1 | INDOLINE COMPOUND AND 5-HT 3? RECEPTOR ANTAGONIST CONTAINING THE SAME AS ACTIVE INGREDIENT | TOKYO TANABE CO (JP) | 1998-01-07 | — | — | EP | disclosed |
| US-5677326-A | GASTROINTESTINAL DISORDERS | TOKYO TANABE COMPANY LIMITED (JP) | 1997-10-14 | — | — | US | disclosed |
| EP-0721949-A1 | INDOLINE COMPOUND AND 5-HT 3? RECEPTOR ANTAGONIST CONTAINING THE SAME AS ACTIVE INGREDIENT | TOKYO TANABE COMPANY LIMITED (JP) | 1996-07-17 | — | — | EP | disclosed |