Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 3/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547177 | 0.88 | TRPM8 (0.38) | LMNATDP1MAPTPOLBKDM4E | |
| SCHEMBL8548708 | 0.81 | PTGDR2 (0.40) | LMNAMAPTPTGDR2POLBPPARD | |
| SCHEMBL8545353 | 0.71 | KDM4E (0.45) | LMNAMAPTPTGDR2POLBPPARD | |
| SCHEMBL4481950 | 0.71 | PTGDR2 (0.42) | LMNATDP1MAPTPTGDR2POLB | |
| SCHEMBL8591219 | 0.71 | KDM5B (0.44) | TDP1MAPTPTGDR2PPARDPPARG | |
| SCHEMBL8548816 | 0.70 | POLB (0.53) | LMNAMAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL10360134 | 0.70 | PTGDR2 (0.39) | LMNAMAPTPTGDR2POLBPPARD | |
| SCHEMBL8591973 | 0.70 | ECE1 (0.42) | TDP1PTGDR2POLBKDM4EALDH1A1 | |
| SCHEMBL11588944 | 0.70 | MAPT (0.43) | LMNATDP1MAPTPTGDR2POLB | |
| SCHEMBL46644 | 0.69 | LMNA (0.40) | LMNAMAPTPTGDR2POLBPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714393-B1 | THIAZOLES AS ANTIVIRAL | PFIZER (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5789408-A | Antiviral thiazoles | PFIZER INC. (US) | 1998-08-04 | — | — | US | disclosed |
| EP-0714393-A1 | THIAZOLES AS ANTIVIRAL | PFIZER INC. (US) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005378-A1 | ANTIVIRAL THIAZOLES | PFIZER INC. (US) | 1995-02-23 | — | — | WO | disclosed |