Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549346 | 0.85 | LMNA (0.53) | KDM4EALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL4481950 | 0.82 | PTGDR2 (0.42) | KDM4EGFERALDH1A1PTGDR2POLB | |
| SCHEMBL8591219 | 0.81 | KDM5B (0.44) | KDM4EALDH1A1PTGDR2SMN1; SMN2NPC1 | |
| SCHEMBL8591973 | 0.81 | ECE1 (0.42) | KDM4EGFERALDH1A1PTGDR2POLB | |
| SCHEMBL8545303 | 0.80 | KDM4E (0.43) | KDM4EGFERALDH1A1PTGDR2POLB | |
| SCHEMBL8551360 | 0.80 | ALDH1A1 (0.46) | KDM4EALDH1A1PTGDR2POLBHPGD | |
| SCHEMBL8550241 | 0.79 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8543453 | 0.79 | CYP1A2 (0.50) | KDM4EALDH1A1PTGDR2POLBLMNA | |
| SCHEMBL8546367 | 0.79 | PPARD (0.46) | ALDH1A1PTGDR2SMN1; SMN2FFAR1PPARD | |
| SCHEMBL8544759 | 0.78 | PPARD (0.41) | KDM4EALDH1A1PTGDR2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714393-B1 | THIAZOLES AS ANTIVIRAL | PFIZER (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5789408-A | Antiviral thiazoles | PFIZER INC. (US) | 1998-08-04 | — | — | US | disclosed |
| EP-0714393-A1 | THIAZOLES AS ANTIVIRAL | PFIZER INC. (US) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005378-A1 | ANTIVIRAL THIAZOLES | PFIZER INC. (US) | 1995-02-23 | — | — | WO | disclosed |