Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 6/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547096 | 0.81 | ALOX15 (0.42) | POLBLMNAHPGDMEN1KMT2A | |
| SCHEMBL8551379 | 0.80 | KDM4E (0.49) | POLBLMNATP53RXFP1HPGD | |
| SCHEMBL4481950 | 0.77 | PTGDR2 (0.42) | POLBLMNAMEN1KMT2AKDM4E | |
| SCHEMBL8545353 | 0.76 | KDM4E (0.45) | POLBLMNATP53HPGDKMT2A | |
| SCHEMBL8550241 | 0.76 | ALDH1A1 (0.50) | TP53RXFP1HTTKDM4EALDH1A1 | |
| SCHEMBL8591973 | 0.75 | ECE1 (0.42) | POLBKDM4EALDH1A1ALOX15 | |
| SCHEMBL8551237 | 0.74 | MEN1 (0.32) | LMNAHPGDHTTMEN1KMT2A | |
| SCHEMBL8591219 | 0.74 | KDM5B (0.44) | KDM4EMAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8545040 | 0.73 | GABRP (0.39) | POLBLMNAMEN1KMT2AKDM4E | |
| SCHEMBL10689661 | 0.72 | ALDH1A1 (0.60) | POLBLMNARXFP1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714393-B1 | THIAZOLES AS ANTIVIRAL | PFIZER (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5789408-A | Antiviral thiazoles | PFIZER INC. (US) | 1998-08-04 | — | — | US | disclosed |
| WO-1995005378-A1 | ANTIVIRAL THIAZOLES | PFIZER INC. (US) | 1995-02-23 | — | — | WO | disclosed |