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SCHEMBL8545547

SCHEMBL8545547

CCC(CC(Oc1cc(OCc2ccccc2)ccc1C(=O)OC)c1ccccc1)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ PPARA Q07869 2/20 0.47
▸ PPARG P37231 1/20 0.44
▸ PPARD Q03181 1/20 0.44
▸ MAOB P27338 1/20 0.43
▸ FFAR4 Q5NUL3 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ EGFR P00533 1/20 0.39
▸ ALOX5AP P20292 1/20 0.39
▸ FFAR1 O14842 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8549667 0.90 MAOB (0.53) PPARAPPARGPPARDMAOB
SCHEMBL8551123 0.89 PARP15 (0.47) PPARAPPARGPPARDMAOB
SCHEMBL8545384 0.89 PPARA (0.50) PPARAPPARGPPARDMAOBALDH1A1
SCHEMBL8551507 0.83 PPARA (0.42) PPARAPPARGPPARDMAOBLMNA
SCHEMBL7914050 0.83 FFAR4 (0.48) MAOBFFAR4
SCHEMBL7914053 0.83 FFAR4 (0.48) MAOBFFAR4
SCHEMBL8550604 0.82 CYP2D6 (0.50) —
SCHEMBL8550070 0.82 KMT2A (0.50) MAOBFFAR1
SCHEMBL8549924 0.82 GPR132 (0.46) MAOB
SCHEMBL8545544 0.81 LMNA (0.44) PPARAPPARGPPARDMAOBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0728128-B1 SUBSTITUTED PHENYL COMPOUNDS RHONE POULENC RORER LTD (GB) 1998-09-16 — — EP claimed