Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | GRK6 | P43250 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429570 | 0.91 | ALDH1A1 (0.38) | ALDH1A1TSHR | |
| SCHEMBL8549059 | 0.91 | ALDH1A1 (0.38) | ALDH1A1TSHRADORA2BMAPTLMNA | |
| SCHEMBL9663223 | 0.91 | AGTR1 (0.30) | — | |
| SCHEMBL8545039 | 0.90 | ALDH1A1 (0.37) | ALDH1A1TSHRADORA2BMAPTLMNA | |
| SCHEMBL9309904 | 0.89 | MAPK1 (0.36) | ALDH1A1TSHRADORA2BMAPTKDM4E | |
| SCHEMBL8543440 | 0.88 | ALDH1A1 (0.36) | ALDH1A1TSHRMAPTLMNAHTT | |
| SCHEMBL9429517 | 0.88 | ALDH1A1 (0.36) | ALDH1A1TSHRKDM4EMEN1HPGD | |
| SCHEMBL9310339 | 0.88 | KDM4E (0.33) | ALDH1A1ADORA2BKDM4EMAPK1SIRT3 | |
| SCHEMBL8548670 | 0.86 | ALDH1A1 (0.35) | ALDH1A1TSHRMAPTLMNAHTT | |
| SCHEMBL9308888 | 0.85 | AGTR1 (0.31) | ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0514198-B1 | 1H-Imidazol-1-yl-methyl benzofuran derivatives with the imidazolyl moiety being substituted by a cycloalkyl group | GLAXO GROUP LTD (GB) | 1998-08-05 | — | — | EP | disclosed |
| US-5498722-A | HYPOTENSIVES | GLAXO GROUP (GB) | 1996-03-12 | — | — | US | disclosed |
| US-5332831-A | Angiotensin antagonist | GLAXO GROUP LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| WO-1992020674-A1 | 1H-IMIDAZOL-1-YL-METHYL BENZOFURAN DERIVATIVES, WITH THE IMIDAZOLYL MOIETY BEING SUBSTITUTED BY A CYCLOALKYL GROUP | GLAXO GROUP LIMITED (GB) | 1992-11-26 | — | — | WO | disclosed |