Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 15/20 | 0.46 |
| ▸ | PPARA | Q07869 | 10/20 | 0.46 |
| ▸ | PPARG | P37231 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.39 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545901 | 0.87 | ALDH1A1 (0.43) | PPARDPPARAPPARGALDH1A1SMN1; SMN2 | |
| SCHEMBL8550265 | 0.83 | PPARD (0.49) | PPARDPPARAPPARGALDH1A1FFAR1 | |
| SCHEMBL8591219 | 0.83 | KDM5B (0.44) | PPARDPPARAPPARGALDH1A1SMN1; SMN2 | |
| SCHEMBL8545353 | 0.79 | KDM4E (0.45) | PPARDALDH1A1SMN1; SMN2FFAR1PTGDR2 | |
| SCHEMBL8544759 | 0.77 | PPARD (0.41) | PPARDPPARAPPARGALDH1A1SMN1; SMN2 | |
| SCHEMBL8548084 | 0.76 | PPARD (0.39) | PPARDPPARAPPARGALDH1A1PTGDR2 | |
| SCHEMBL5016724 | 0.73 | ALDH1A1 (0.70) | PPARDPPARAPPARGALDH1A1SMN1; SMN2 | |
| SCHEMBL8551360 | 0.72 | ALDH1A1 (0.46) | PPARDPPARAPPARGALDH1A1PTGDR2 | |
| SCHEMBL5474625 | 0.72 | PPARD (0.62) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL4481950 | 0.72 | PTGDR2 (0.42) | PPARDALDH1A1SMN1; SMN2FFAR1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714393-B1 | THIAZOLES AS ANTIVIRAL | PFIZER (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5789408-A | Antiviral thiazoles | PFIZER INC. (US) | 1998-08-04 | — | — | US | disclosed |
| EP-0828721-A1 | 2-AMINO-BENZOXAZINONES FOR THE TREATMENT OF VIRAL INFECTIONS | G.D. SEARLE & CO. (US) | 1998-03-18 | — | — | EP | disclosed |
| EP-0714393-A1 | THIAZOLES AS ANTIVIRAL | PFIZER INC. (US) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005378-A1 | ANTIVIRAL THIAZOLES | PFIZER INC. (US) | 1995-02-23 | — | — | WO | disclosed |