Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546628 | 0.89 | ALDH1A1 (0.42) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL8550265 | 0.82 | PPARD (0.49) | ALDH1A1KDM4EPPARGPPARDPPARA | |
| SCHEMBL8591219 | 0.82 | KDM5B (0.44) | ALDH1A1KDM4EMAPTPPARGPPARD | |
| SCHEMBL8545353 | 0.80 | KDM4E (0.45) | ALDH1A1CYP1A2HPGDHSD17B10KDM4E | |
| SCHEMBL8673850 | 0.79 | ALDH1A1 (0.41) | ALDH1A1CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL8591973 | 0.77 | ECE1 (0.42) | ALDH1A1CYP1A2KDM4EPOLBPTGDR2 | |
| SCHEMBL8548708 | 0.76 | PTGDR2 (0.40) | ALDH1A1HPGDKDM4EMAPTPPARG | |
| SCHEMBL10690460 | 0.75 | LMNA (0.54) | ALDH1A1HPGDKDM4EMAPTPOLB | |
| SCHEMBL4481950 | 0.75 | PTGDR2 (0.42) | ALDH1A1CYP1A2KDM4EMAPTPPARD | |
| SCHEMBL11588944 | 0.74 | MAPT (0.43) | ALDH1A1KDM4EMAPTGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714393-B1 | THIAZOLES AS ANTIVIRAL | PFIZER (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5789408-A | Antiviral thiazoles | PFIZER INC. (US) | 1998-08-04 | — | — | US | disclosed |
| EP-0714393-A1 | THIAZOLES AS ANTIVIRAL | PFIZER INC. (US) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005378-A1 | ANTIVIRAL THIAZOLES | PFIZER INC. (US) | 1995-02-23 | — | — | WO | disclosed |