Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 7/20 | 0.64 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8553003 | 0.98 | GRIN2B (0.62) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL8923198 | 0.80 | KDM4E (0.54) | GRIN2BOPRL1OPRM1OPRK1BCHE | |
| SCHEMBL8673995 | 0.79 | GRIN2B (0.68) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL9947176 | 0.79 | GRIN2B (0.68) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL9727205 | 0.79 | GRIN2B (0.68) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL3519807 | 0.78 | RAB9A (0.48) | — | |
| SCHEMBL8569629 | 0.78 | GRIN2B (0.62) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL9947164 | 0.77 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL7436031 | 0.77 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL9018525 | 0.77 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0822814-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-12-09 | — | — | EP | disclosed |
| EP-0822814-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-02-11 | — | — | EP | disclosed |
| WO-1996032938-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-10-24 | — | — | WO | disclosed |