SCHEMBL8548458

SCHEMBL8548458

COc1ccc2[nH]cc(CCN3CCCC3)c2c1Cl

nearest known ligand 0.74

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 2/20 0.74
HTR2A P28223 7/20 0.55
HTR2C P28335 2/20 0.53
HTR2B P41595 2/20 0.53
HRH3 Q9Y5N1 1/20 0.50
HTR1D P28221 6/20 0.48
HTR1B P28222 6/20 0.48
MPO P05164 1/20 0.47
SIGMAR1 Q99720 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20970863 0.85 HTR1A (1.00) HTR1AHTR2AHTR2CHTR2BHRH3
SCHEMBL29633073 0.85 HTR1A (1.00) HTR1AHTR2AHTR2CHTR2BHRH3
SCHEMBL32669417 0.84 HTR1A (0.98) HTR1AHTR2AHTR2CHTR2BHRH3
SCHEMBL24723416 0.82 HTR1A (0.70) HTR1AHTR2AHTR2CHTR2BHRH3
SCHEMBL26508356 0.80 HTR1A (0.66) HTR1AHTR2AHTR2CHTR2BHRH3
SCHEMBL2541508 0.79 HTR2A (0.65) HTR1AHTR2AHTR2CHTR2BHTR1D
SCHEMBL8544722 0.78 HTR2A (0.53) HTR1AHTR2AHTR2CHTR2BHTR1D
SCHEMBL8543450 0.76 HTR1A (0.71) HTR1AHTR2AHTR2CHTR2BHTR1D
SCHEMBL8548455 0.76 SLC6A4 (0.49) HTR1AHTR2A
SCHEMBL8549023 0.73 MPO (0.48) HTR1AHTR2AHTR1DMPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP claimed
US-5571833-A TREATMENT OF MIGRAINE, PORTAL HYPERTENSION SMITHKLINE BEECHAM PLC (GB) 1996-11-05 US claimed
EP-0593513-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1994-04-27 EP claimed
WO-1993000333-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-01-07 WO claimed
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP disclosed
US-5571833-A TREATMENT OF MIGRAINE, PORTAL HYPERTENSION SMITHKLINE BEECHAM PLC (GB) 1996-11-05 US disclosed
EP-0593513-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1994-04-27 EP disclosed
WO-1993000333-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-01-07 WO disclosed