Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552543 | 0.90 | AGTR1 (0.38) | AGTR2AGTR1 | |
| SCHEMBL6605204 | 0.85 | AGTR1 (0.38) | AGTR2AGTR1 | |
| SCHEMBL6610731 | 0.83 | AGTR2 (0.51) | ALDH1A1AGTR2AGTR1RAB9AKDM4E | |
| SCHEMBL6607743 | 0.83 | HTT (0.41) | AGTR2AGTR1HTT | |
| SCHEMBL8944271 | 0.81 | AGTR2 (0.36) | ALDH1A1AGTR2AGTR1KDM4ENPSR1 | |
| SCHEMBL8944450 | 0.80 | LMNA (0.39) | ALDH1A1AGTR2AGTR1RAB9AKDM4E | |
| SCHEMBL8548646 | 0.77 | AGTR1 (0.39) | ALDH1A1AGTR2AGTR1 | |
| SCHEMBL8548756 | 0.77 | AGTR1 (0.37) | AGTR2AGTR1 | |
| SCHEMBL6606968 | 0.76 | AGTR1 (0.47) | AGTR2AGTR1 | |
| SCHEMBL6606053 | 0.75 | AGTR1 (0.50) | ALDH1A1AGTR2AGTR1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588299-B1 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0829479-A1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |
| US-5500427-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0588299-A2 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |