Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944158 | 0.84 | JMJD6 (0.39) | NPSR1AGTR1AGTR2TP53 | |
| SCHEMBL8944331 | 0.81 | AGTR1 (0.51) | LMNAALDH1A1NPSR1AGTR1AGTR2 | |
| SCHEMBL8548644 | 0.80 | ALDH1A1 (0.36) | LMNAALDH1A1NPSR1AGTR1AGTR2 | |
| SCHEMBL8944447 | 0.79 | AGTR1 (0.36) | AGTR1AGTR2KDM4ETP53 | |
| SCHEMBL8944455 | 0.76 | AGTR1 (0.43) | ALDH1A1AGTR1AGTR2 | |
| SCHEMBL6610008 | 0.75 | AGTR1 (0.39) | AGTR1AGTR2RAB9ANPC1TP53 | |
| SCHEMBL8549892 | 0.73 | LMNA (0.36) | LMNAALDH1A1RAB9AMAPTNPC1 | |
| SCHEMBL8944162 | 0.70 | AGTR1 (0.54) | AGTR1AGTR2 | |
| SCHEMBL8548779 | 0.69 | LTB4R2 (0.48) | AGTR1AGTR2 | |
| SCHEMBL6604865 | 0.69 | AGTR1 (0.43) | AGTR1AGTR2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500427-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-19 | — | — | US | disclosed |