Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CES2 | O00748 | 3/20 | 0.34 |
| ▸ | CES1 | P23141 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7087828 | 0.81 | SMN1; SMN2 (0.37) | ALDH1A1LMNASLC6A2SLC6A3RAB9A | |
| SCHEMBL8154820 | 0.70 | ALDH1A1 (0.39) | ALDH1A1LMNAGAASLC6A2SLC6A3 | |
| SCHEMBL28513170 | 0.68 | HPGD (0.32) | MAPTHPGDHTT | |
| SCHEMBL15680018 | 0.66 | CES2 (0.63) | ALDH1A1LMNAHPGDCES2CES1 | |
| SCHEMBL5444935 | 0.66 | CES2 (0.63) | ALDH1A1LMNAHPGDCES2CES1 | |
| SCHEMBL12763852 | 0.66 | — | — | |
| SCHEMBL7508732 | 0.66 | NPC1 (0.36) | ALDH1A1LMNASLC6A2SLC6A3RAB9A | |
| SCHEMBL2297437 | 0.65 | ALDH1A1 (0.53) | ALDH1A1LMNACES2CES1KDM4E | |
| SCHEMBL5781172 | 0.65 | MMP2 (0.38) | ALDH1A1LMNASLC6A2SLC6A3MAPT | |
| SCHEMBL7550562 | 0.65 | ALOX5 (0.41) | SLC6A2SLC6A3CES2CES1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |