Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 7/20 | 0.42 |
| ▸ | HTR2A | P28223 | 7/20 | 0.42 |
| ▸ | DRD3 | P35462 | 7/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.36 |
| ▸ | TEK | Q02763 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8704542 | 0.90 | ALDH1A1 (0.53) | ALDH1A1DRD2HTR2ADRD3SMN1; SMN2 | |
| SCHEMBL8549413 | 0.86 | ALDH1A1 (0.40) | ALDH1A1DRD2HTR2ADRD3TP53 | |
| SCHEMBL8552088 | 0.84 | DRD2 (0.39) | ALDH1A1DRD2HTR2ADRD3TP53 | |
| SCHEMBL7489588 | 0.81 | HTR1D (0.56) | DRD2 | |
| SCHEMBL8548440 | 0.81 | CA2 (0.43) | CA2ALDH1A1DRD2MEN1KMT2A | |
| SCHEMBL8703766 | 0.79 | UBE2M (0.44) | UBE2MDCUN1D1 | |
| Hydrochloric Acid SCHEMBL8549247 | 0.78 | TP53 (0.46) | DRD2HTR2ADRD3TP53MAPT | |
| SCHEMBL8548758 | 0.78 | DRD2 (0.40) | ALDH1A1DRD2HTR2ADRD3TP53 | |
| SCHEMBL8703395 | 0.75 | DRD2 (0.61) | DRD2HTR2ADRD3 | |
| SCHEMBL8548045 | 0.75 | DRD2 (0.34) | ALDH1A1DRD2HTR2ADRD3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |