Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.39 |
| ▸ | HTR2A | P28223 | 12/20 | 0.39 |
| ▸ | DRD3 | P35462 | 12/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.34 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548045 | 0.90 | DRD2 (0.34) | DRD2HTR2ADRD3ALDH1A1HTT | |
| SCHEMBL8704542 | 0.85 | ALDH1A1 (0.53) | DRD2HTR2ADRD3ALDH1A1EPHX2 | |
| SCHEMBL8548755 | 0.84 | CA2 (0.43) | DRD2HTR2ADRD3MAPTTP53 | |
| SCHEMBL7483808 | 0.82 | HTR1D (0.55) | DRD2 | |
| SCHEMBL8549413 | 0.81 | ALDH1A1 (0.40) | DRD2HTR2ADRD3MAPTTP53 | |
| Hydrochloric Acid SCHEMBL8549247 | 0.75 | TP53 (0.46) | DRD2HTR2ADRD3MAPTTP53 | |
| SCHEMBL8547778 | 0.75 | DRD2 (0.41) | DRD2HTR2ADRD3MAPTRAB9A | |
| SCHEMBL8548758 | 0.75 | DRD2 (0.40) | DRD2HTR2ADRD3TP53ALDH1A1 | |
| SCHEMBL8552340 | 0.73 | DRD2 (0.47) | DRD2HTR2ADRD3MAPT | |
| SCHEMBL8546763 | 0.73 | HTR1D (0.45) | DRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |