Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 8/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL854865 | 0.83 | MAPT (0.46) | CYP3A4ALDH1A1TSHRGPR35KDM4E | |
| SCHEMBL855671 | 0.81 | TDP1 (0.50) | CYP3A4ALDH1A1TSHRLMNAGPR35 | |
| SCHEMBL855457 | 0.81 | TSHR (0.36) | CYP3A4ALDH1A1TSHRLMNAGPR35 | |
| SCHEMBL3649190 | 0.80 | CYP19A1 (0.46) | CYP19A1AAK1CYP3A4ALDH1A1TSHR | |
| SCHEMBL855859 | 0.79 | VCAM1 (0.42) | CYP19A1CYP3A4ALDH1A1TSHRLMNA | |
| SCHEMBL855601 | 0.78 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPT | |
| SCHEMBL4312639 | 0.76 | LOXL2 (0.52) | ALDH1A1TSHRPOLB | |
| SCHEMBL9488146 | 0.75 | KAT2B (0.49) | CYP19A1AAK1CYP3A4ALDH1A1TSHR | |
| SCHEMBL15248984 | 0.75 | ALDH1A1 (0.47) | CYP19A1AAK1CYP3A4ALDH1A1TSHR | |
| SCHEMBL27748882 | 0.75 | CYP19A1 (0.43) | CYP19A1AAK1CYP3A4ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9055749-B2 | Insecticidal arylpyrrolines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-06-16 | — | — | US | disclosed |
| EP-2432762-B1 | INSECTICIDAL ARYLPYRROLINES | BAYER CROPSCIENCE AG (DE) | 2015-02-25 | — | — | EP | disclosed |
| EP-2242739-B1 | INSECTICIDAL ARYLPYRROLINES | BAYER CROPSCIENCE AG (DE) | 2014-11-12 | — | — | EP | disclosed |
| US-20140024680-A1 | Insecticidal Arylpyrrolines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-01-23 | — | — | US | disclosed |
| US-8410141-B2 | Insecticidal arylpyrrolines | BAYER CROPSCIENCE AG (DE) | 2013-04-02 | — | — | US | disclosed |
| US-8304371-B2 | Insecticidal arylpyrrolines | BAYER CROPSCIENCE AG (DE) | 2012-11-06 | — | — | US | disclosed |
| US-20120108635-A1 | Insecticidal Arylpyrrolines | BAYER CROPSCIENCE AG (DE) | 2012-05-03 | — | — | US | disclosed |
| EP-2432762-A1 | INSECTICIDAL ARYLPYRROLINES | Bayer CropScience AG (DE) | 2012-03-28 | — | — | EP | disclosed |
| US-20110003690-A1 | INSECTICIDAL ARYLPYRROLINES | BAY CROPSCIENCE AG (DE) | 2011-01-06 | — | — | US | disclosed |
| WO-2010133336-A1 | INSECTICIDAL ARYLPYRROLINES | BAYER CROPSCIENCE AG (DE) | 2010-11-25 | — | — | WO | disclosed |
| EP-2242739-A1 | INSECTICIDAL ARYLPYRROLINES | Bayer CropScience AG (DE) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009097992-A1 | INSECTICIDAL ARYLPYRROLINES | BAYER CROPSCIENCE AG (DE) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003690-A1 | INSECTICIDAL ARYLPYRROLINES | DDT, ACHE, CYP1A2 | CYP19A1 96/4885AAK1 1959/4885CYP3A4 205/4885 |
| US-20140024680-A1 | Insecticidal Arylpyrrolines | DDT, ACHE, CYP1A2 | CYP19A1 75/4885AAK1 1558/4885CYP3A4 173/4885 |
| US-20120108635-A1 | Insecticidal Arylpyrrolines | DDT, ACHE, CYP1A2 | CYP19A1 75/4885AAK1 1558/4885CYP3A4 173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.