Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543192 | 1.00 | HSD11B1 (0.54) | HSD11B1RAB9AKDM4EMAPTAGTR1 | |
| SCHEMBL8544264 | 0.85 | HSD11B1 (0.46) | HSD11B1KDM4EMAPTEPHX1ALDH1A1 | |
| SCHEMBL8544257 | 0.85 | HSD11B1 (0.46) | HSD11B1KDM4EMAPTEPHX1ALDH1A1 | |
| SCHEMBL8549491 | 0.83 | KMT2A (0.47) | HSD11B1KDM4EMEN1KMT2AEPHX1 | |
| SCHEMBL8549484 | 0.83 | KMT2A (0.47) | HSD11B1KDM4EMEN1KMT2AEPHX1 | |
| SCHEMBL8543196 | 0.82 | HSD11B1 (0.62) | HSD11B1KDM4EMEN1GAAKMT2A | |
| SCHEMBL8543030 | 0.79 | KMT2A (0.52) | HSD11B1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8543046 | 0.79 | KMT2A (0.52) | HSD11B1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8548645 | 0.77 | CTSK (0.46) | HSD11B1RAB9AKDM4EAGTR1MEN1 | |
| SCHEMBL8548638 | 0.77 | CTSK (0.46) | HSD11B1RAB9AKDM4EAGTR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564924-B1 | 2-Oxoethyl derivatives as immunosuppressants | BAYER AG (US) | 1998-09-09 | — | — | EP | claimed |
| EP-0564924-A2 | 2-Oxoethyl derivatives as immunosuppressants | Bayer Corporation (US) | 1993-10-13 | — | — | EP | claimed |
| EP-0564924-B1 | 2-Oxoethyl derivatives as immunosuppressants | BAYER AG (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5686424-A | FOR TREATING INFLAMMATION | MILES INC. (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0564924-A2 | 2-Oxoethyl derivatives as immunosuppressants | Bayer Corporation (US) | 1993-10-13 | — | — | EP | disclosed |