Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoromethanesulfonic Acid SCHEMBL7137485 | 0.88 | POLB (0.38) | — | |
| SCHEMBL8931318 | 0.81 | ALDH1A1 (0.38) | MAPTSMN1; SMN2USP2ALDH1A1LMNA | |
| Trifluoromethanesulfonic Acid SCHEMBL8545942 | 0.76 | MGLL (0.36) | MAPTUSP2MCHR1 | |
| Trifluoromethanesulfonic Acid SCHEMBL8551955 | 0.67 | KDM4E (0.37) | MAPTALDH1A1HTT | |
| SCHEMBL240595 | 0.59 | SMN1; SMN2 (0.75) | MAPTSMN1; SMN2ALDH1A1HTTHSD17B10 | |
| SCHEMBL31484185 | 0.59 | SMN1; SMN2 (0.75) | MAPTSMN1; SMN2ALDH1A1HTTHSD17B10 | |
| SCHEMBL12031204 | 0.57 | SMN1; SMN2 (0.43) | MAPTSMN1; SMN2USP2ALDH1A1LMNA | |
| SCHEMBL18364999 | 0.57 | HSD17B10 (0.65) | MAPTSMN1; SMN2ALDH1A1HTTHSD17B10 | |
| SCHEMBL27459830 | 0.57 | ALDH1A1 (0.64) | MAPTSMN1; SMN2USP2ALDH1A1LMNA | |
| SCHEMBL84403 | 0.56 | NPC1 (0.67) | MAPTSMN1; SMN2ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |