Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.41 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13124568 | 0.86 | PPARA (0.43) | PPARGPPARASLC6A4 | |
| SCHEMBL10372698 | 0.82 | SLC6A4 (0.41) | PPARGPPARASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9483615 | 0.79 | CYP1A2 (0.46) | PPARGPPARAMAPTNPC1 | |
| SCHEMBL28847136 | 0.78 | ALDH1A3 (0.55) | KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL27566411 | 0.78 | P2RX3 (0.42) | ACHEKMT2AMEN1CA12CA2 | |
| SCHEMBL13607574 | 0.77 | MMP13 (0.40) | KMT2ACA12CA2CA9ALDH1A1 | |
| SCHEMBL7450095 | 0.77 | PPARG (0.50) | PPARGPPARAKMT2AMEN1HTR1A | |
| SCHEMBL11233033 | 0.76 | MTNR1A (0.41) | PPARGPPARASLC6A4KMT2AALDH1A1 | |
| SCHEMBL10694597 | 0.76 | KMT2A (0.40) | PPARGPPARAACHEKMT2AMEN1 | |
| SCHEMBL15871120 | 0.76 | ACHE (0.38) | PPARGPPARAACHEKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842174-A1 | HETEROCYCLIC COMPOUNDS FOR TREATING MYOCARDIAL ISCHAEMIA | PIERRE FABRE MEDICAMENT (FR) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997005134-A1 | HETEROCYCLIC COMPOUNDS FOR TREATING MYOCARDIAL ISCHAEMIA | PIERRE FABRE MEDICAMENT (FR) | 1997-02-13 | — | — | WO | disclosed |