Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 4/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.53 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.53 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547677 | 0.90 | CARM1 (0.47) | GRIN2BADRA1DADRA1AADRA1BGRIN2D | |
| SCHEMBL8547315 | 0.84 | GRIN2B (0.51) | GRIN2BADRA1DADRA1AADRA1BGRIN2D | |
| SCHEMBL8540534 | 0.83 | CARM1 (0.43) | GRIN2BMAOAMAOBMEN1KMT2A | |
| SCHEMBL8547312 | 0.81 | MAOA (0.54) | GRIN2BADRA1DADRA1AADRA1BGRIN2D | |
| SCHEMBL7305064 | 0.80 | CHRM2 (0.46) | GRIN2BMAOAMAOBCHRM2CHRM4 | |
| SCHEMBL8549343 | 0.80 | GRIN2B (0.59) | GRIN2BADRA1DADRA1AADRA1BGRIN2D | |
| SCHEMBL8542975 | 0.79 | MAOA (0.49) | GRIN2BADRA1DADRA1AADRA1BMAOA | |
| SCHEMBL11071104 | 0.77 | MAOA (0.61) | ADRA1DADRA1AADRA1BMAOAMAOB | |
| SCHEMBL11069444 | 0.76 | DRD4 (0.62) | ADRB2ADRB1DRD2DRD4MEN1 | |
| SCHEMBL8543860 | 0.76 | LMNA (0.37) | GRIN2BMEN1KMT2ACCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709384-B1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | EP | disclosed |
| EP-0709384-A1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GmbH (DE) | 1996-05-01 | — | — | EP | disclosed |