Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.40 |
| ▸ | FEN1 | P39748 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561414 | 0.89 | PTGS2 (0.47) | PTGS2PTGS1RXRAALOX5APFEN1 | |
| SCHEMBL6315005 | 0.88 | PTGS2 (0.45) | PTGS2PTGS1RXRAALOX5APFEN1 | |
| SCHEMBL6315419 | 0.87 | PTGS2 (0.44) | PTGS2PTGS1RXRAALOX5APFEN1 | |
| SCHEMBL6315591 | 0.87 | PTGS2 (0.44) | PTGS2PTGS1RXRAALOX5APFEN1 | |
| SCHEMBL6310277 | 0.85 | RXRA (0.47) | PTGS2PTGS1RXRAF10 | |
| SCHEMBL8549849 | 0.84 | PTGS2 (0.57) | PTGS2PTGS1 | |
| SCHEMBL6308551 | 0.84 | RXRA (0.44) | PTGS2PTGS1RXRAF10 | |
| SCHEMBL8556142 | 0.82 | PTGS2 (0.46) | PTGS2PTGS1RXRAALOX5APFEN1 | |
| Methane SCHEMBL6310824 | 0.81 | PTGS2 (0.48) | PTGS2PTGS1ALOX5APFEN1L3MBTL1 | |
| SCHEMBL8560736 | 0.81 | PTGS2 (0.47) | PTGS2PTGS1RXRAALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | claimed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | claimed |
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |