Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8591475 | 0.93 | PTPN1 (0.42) | PTPN1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8553723 | 0.90 | FFAR1 (0.44) | CTSVCTSLPTPN1FFAR1PPARD | |
| SCHEMBL8552525 | 0.88 | ELANE (0.38) | PTPN1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8553299 | 0.87 | PTPN1 (0.38) | PTPN1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8553319 | 0.85 | PDE4B (0.40) | PTPN1ELANEALDH1A1MAPTHPGD | |
| SCHEMBL8551848 | 0.79 | CTSV (0.52) | CTSVCTSLSRD5A1SRD5A2TUBB4A | |
| SCHEMBL8697633 | 0.79 | POLB (0.37) | SRD5A1SRD5A2PTPN1HDAC8 | |
| SCHEMBL8697275 | 0.77 | PTPN1 (0.42) | PTPN1ALDH1A1MAPT | |
| SCHEMBL8553266 | 0.76 | EDNRB (0.56) | CTSVCTSLSRD5A1SRD5A2ALDH1A1 | |
| SCHEMBL8546890 | 0.74 | EDNRB (0.44) | CTSVCTSLSRD5A1SRD5A2TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |