Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8591475 | 0.93 | PTPN1 (0.42) | ELANEPTPN1KDM4EALDH1A1HPGD | |
| SCHEMBL8550982 | 0.88 | CTSV (0.44) | ELANEPTPN1ALDH1A1HPGDMAPT | |
| SCHEMBL8553299 | 0.88 | PTPN1 (0.38) | SERPINE1PTPN1KDM4EALDH1A1HPGD | |
| SCHEMBL8553319 | 0.85 | PDE4B (0.40) | ELANEPTPN1KDM4EALDH1A1HPGD | |
| SCHEMBL8553723 | 0.79 | FFAR1 (0.44) | PTPN1ALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL8551010 | 0.78 | KDM4E (0.47) | ELANEKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL8549519 | 0.78 | KDM4E (0.38) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL8697275 | 0.74 | PTPN1 (0.42) | PTPN1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8547163 | 0.73 | EDNRB (0.45) | ELANEPTPN1F2KDM4EGAA | |
| SCHEMBL8546754 | 0.73 | NPC1 (0.40) | KDM4EALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |