Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8591475 | 0.94 | PTPN1 (0.42) | PTPN1KMT2AMEN1MAPTNPSR1 | |
| SCHEMBL8550982 | 0.87 | CTSV (0.44) | PTPN1MAPTALDH1A1HPGDGABRA1 | |
| SCHEMBL8553319 | 0.86 | PDE4B (0.40) | PTPN1KMT2AMEN1MAPTBLM | |
| SCHEMBL8553723 | 0.80 | FFAR1 (0.44) | PTPN1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL8594175 | 0.76 | ALDH1A1 (0.39) | KMT2AMEN1MAPTNPSR1L3MBTL1 | |
| SCHEMBL8551010 | 0.75 | KDM4E (0.47) | KMT2AMEN1MAPTKDM4EALDH1A1 | |
| SCHEMBL8697275 | 0.75 | PTPN1 (0.42) | PTPN1MAPTALDH1A1SMN1; SMN2ADORA2B | |
| SCHEMBL8547478 | 0.73 | EDNRB (0.43) | PTPN1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL8552363 | 0.71 | NPC1 (0.41) | KMT2AMEN1NPSR1KDM4EALDH1A1 | |
| SCHEMBL8552481 | 0.71 | AKR1C2 (0.51) | PTPN1KMT2AMEN1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |