Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133091 | 0.85 | HCAR2 (0.61) | LMNAALDH1A1L3MBTL1MAPTNPC1 | |
| SCHEMBL18355142 | 0.83 | HCAR2 (0.56) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL10876313 | 0.80 | ALDH1A1 (0.73) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL15745845 | 0.79 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL3487087 | 0.79 | LMNA (0.61) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL137308 | 0.78 | LMNA (0.65) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL15745846 | 0.78 | SMN1; SMN2 (0.65) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL15216787 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL27647417 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL13035566 | 0.77 | LMNA (0.55) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | claimed |
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |