SCHEMBL8551087

SCHEMBL8551087

O=C(OC1CCN(Cc2ccccc2)CC1)c1ccc(I)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 4/20 0.62
TMEM97 Q5BJF2 2/20 0.62
CYP1A2 P05177 1/20 0.62
CYP3A4 P08684 1/20 0.62
CYP2D6 P10635 1/20 0.62
CYP2C9 P11712 1/20 0.62
TSHR P16473 1/20 0.62
MAPK1 P28482 1/20 0.62
CYP2C19 P33261 1/20 0.62
BCHE P06276 2/20 0.58
DRD2 P14416 1/20 0.55
DRD4 P21917 1/20 0.55
HTR2A P28223 1/20 0.54
CARM1 Q86X55 1/20 0.54
PRMT6 Q96LA8 1/20 0.54
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52
SCN1A P35498 1/20 0.52
SCN2A Q99250 1/20 0.52
SCN3A Q9NY46 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8686889 0.99 SIGMAR1 (0.61) SIGMAR1TMEM97CYP1A2CYP3A4CYP2D6
SCHEMBL8550490 0.91 BCHE (0.65) BCHEDRD2DRD4CARM1PRMT6
Hydrochloric Acid SCHEMBL8556315 0.89 MEN1 (0.65) BCHEDRD2DRD4CARM1PRMT6
SCHEMBL8553033 0.88 DRD2 (0.70) SIGMAR1BCHEDRD2DRD4CARM1
SCHEMBL8552599 0.88 SIGMAR1 (0.64) SIGMAR1TMEM97BCHEDRD2DRD4
SCHEMBL8553724 0.87 BCHE (0.58) SIGMAR1TMEM97BCHEDRD2DRD4
SCHEMBL8549828 0.87 CHRM2 (0.59) SIGMAR1CYP3A4CYP2D6MAPK1CYP2C19
SCHEMBL8550662 0.87 SCN1A (0.63) MAPK1BCHEDRD2DRD4CARM1
Hydrochloric Acid SCHEMBL8551795 0.87 DRD2 (0.68) SIGMAR1BCHEDRD2DRD4CARM1
Hydrochloric Acid SCHEMBL8553699 0.87 SIGMAR1 (0.62) SIGMAR1TMEM97BCHEDRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1084329-C Benzyl piepridine derivs as pharmaceutical agents HOFFMANN LA ROCHE (CH) 2002-05-08 CN claimed
EP-0871613-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 1998-10-21 EP claimed
US-5753679-A SCIZOPHRENIA HOFFMANN-LA ROCHE INC. (US) 1998-05-19 US claimed
WO-1996035666-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 1996-11-14 WO claimed
CN-1084329-C Benzyl piepridine derivs as pharmaceutical agents HOFFMANN LA ROCHE (CH) 2002-05-08 CN disclosed
EP-0871613-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 1998-10-21 EP disclosed
CN-1183768-A Benzyl piepridine derivs as pharmaceutical agents HOFFMANN LA ROCHE (CH) 1998-06-03 CN disclosed
US-5753679-A SCIZOPHRENIA HOFFMANN-LA ROCHE INC. (US) 1998-05-19 US disclosed
WO-1996035666-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 1996-11-14 WO disclosed