Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.64 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.64 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.64 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.64 |
| ▸ | BCHE | P06276 | 2/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8553699 | 0.99 | SIGMAR1 (0.62) | SIGMAR1SLC6A12TMEM97MCHR1BCHE | |
| SCHEMBL8552224 | 0.95 | CARM1 (0.58) | SIGMAR1SLC6A12TMEM97MCHR1BCHE | |
| Hydrochloric Acid SCHEMBL8551179 | 0.94 | MEN1 (0.59) | SIGMAR1SLC6A12TMEM97MCHR1BCHE | |
| SCHEMBL8550490 | 0.92 | BCHE (0.65) | BCHEDRD2DRD4ACHE | |
| Hydrochloric Acid SCHEMBL8556315 | 0.91 | MEN1 (0.65) | BCHEDRD2DRD4ACHE | |
| SCHEMBL8553033 | 0.90 | DRD2 (0.70) | SIGMAR1BCHEDRD2DRD4 | |
| SCHEMBL8551087 | 0.88 | SIGMAR1 (0.62) | SIGMAR1SLC6A12TMEM97MCHR1BCHE | |
| SCHEMBL8550662 | 0.88 | SCN1A (0.63) | BCHEDRD2DRD4 | |
| SCHEMBL8550198 | 0.88 | ADRB2 (0.57) | DRD2DRD4 | |
| SCHEMBL8553724 | 0.88 | BCHE (0.58) | SIGMAR1SLC6A12TMEM97MCHR1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1084329-C | Benzyl piepridine derivs as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2002-05-08 | — | — | CN | disclosed |
| EP-0871613-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-10-21 | — | — | EP | disclosed |
| CN-1183768-A | Benzyl piepridine derivs as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 1998-06-03 | — | — | CN | disclosed |
| US-5753679-A | SCIZOPHRENIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1996035666-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 1996-11-14 | — | — | WO | disclosed |