Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | F13A1 | P00488 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | TGM1 | P22735 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551784 | 0.85 | HTT (0.46) | LMNARAB9AMAPTALDH1A1HTT | |
| SCHEMBL8554012 | 0.79 | SMN1; SMN2 (0.56) | RAB9AHTTENPP2SMN1; SMN2NPC1 | |
| SCHEMBL3594917 | 0.77 | SMN1; SMN2 (0.51) | LMNARAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8551545 | 0.75 | ENPP2 (0.42) | LMNARAB9AMAPTALDH1A1ENPP2 | |
| SCHEMBL16392290 | 0.75 | MAPT (0.54) | LMNAMAPTALDH1A1PTPN1SMN1; SMN2 | |
| SCHEMBL2806642 | 0.75 | ENPP2 (0.47) | RAB9AENPP2NPC1 | |
| SCHEMBL2809066 | 0.74 | GRIN2B (0.47) | LMNAMAPTALDH1A1ENPP2SMN1; SMN2 | |
| SCHEMBL17766775 | 0.74 | TDP1 (0.51) | LMNARAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1118236 | 0.73 | GPR119 (0.51) | RAB9ASMN1; SMN2NPC1GRIN2B | |
| SCHEMBL2806832 | 0.72 | JAK2 (0.44) | ENPP2USP30FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858457-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | Dr. Karl Thomae GmbH (DE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997015567-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | DR. KARL THOMAE GMBH (DE) | 1997-05-01 | — | — | WO | disclosed |