Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.53 |
| ▸ | HTR1D | P28221 | 10/20 | 0.43 |
| ▸ | HTR1B | P28222 | 9/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476269 | 0.81 | HTR1D (0.67) | DRD2HTR1DHTR1B | |
| SCHEMBL8551462 | 0.81 | DRD2 (0.53) | DRD2SLC6A4 | |
| SCHEMBL7476264 | 0.81 | HTR1D (0.67) | DRD2HTR1DHTR1B | |
| SCHEMBL8551459 | 0.81 | DRD2 (0.53) | DRD2SLC6A4 | |
| SCHEMBL8552203 | 0.80 | CCR2 (0.43) | DRD2SLC6A4HTR1DHTR1B | |
| SCHEMBL8553525 | 0.80 | DRD2 (0.43) | DRD2SLC6A4HTR1DHTR1BSMN1; SMN2 | |
| SCHEMBL8550541 | 0.79 | DRD2 (0.52) | DRD2SLC6A4SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL8551607 | 0.79 | DRD2 (0.57) | DRD2SLC6A4 | |
| SCHEMBL8551605 | 0.78 | DRD2 (0.56) | DRD2SLC6A4SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL8550557 | 0.77 | DRD2 (0.43) | DRD2SLC6A4HTR1DHTR1BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |