SCHEMBL8551240

SCHEMBL8551240

CCC(O)CC(c1ccc(Br)cc1)c1cccnc1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.44
LMNA P02545 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
TBXAS1 P24557 3/20 0.40
PDE4D Q08499 1/20 0.40
CFTR P13569 1/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
SLC6A3 Q01959 1/20 0.39
GOPC Q9HD26 1/20 0.39
KCNA5 P22460 2/20 0.39
GAA P10253 1/20 0.38
CYP17A1 P05093 1/20 0.38
HTR2A P28223 1/20 0.38
ADRB2 P07550 1/20 0.38
ADRB1 P08588 1/20 0.38
ADRB3 P13945 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL5999471 0.84 SLC6A4 (0.44) SMN1; SMN2LMNAL3MBTL1TBXAS1PDE4D
SCHEMBL8550753 0.82 TBXAS1 (0.45) SMN1; SMN2LMNAL3MBTL1TBXAS1PDE4D
Oxalic Acid SCHEMBL11567257 0.77 TBXAS1 (0.46) SMN1; SMN2LMNATBXAS1PDE4DKCNA5
Hydrochloric Acid SCHEMBL8555644 0.77 CYP3A4 (0.44) SMN1; SMN2LMNAL3MBTL1PDE4DSLC6A2
SCHEMBL8551012 0.76 PDE4D (0.47) PDE4DSLC6A2SLC6A4SLC6A3KCNA5
SCHEMBL1034162 0.76 HTR2A (0.68) SMN1; SMN2TBXAS1CFTRSLC6A2SLC6A4
SCHEMBL998487 0.75 PDE4D (0.42) SMN1; SMN2LMNATBXAS1PDE4DCFTR
SCHEMBL8554087 0.75 KCNA5 (0.46) SMN1; SMN2LMNAL3MBTL1PDE4DKCNA5
SCHEMBL2403430 0.75 LMNA (0.58) LMNAL3MBTL1SLC6A3GAAHTR2A
SCHEMBL8775798 0.74 SMN1; SMN2 (0.58) SMN1; SMN2LMNAL3MBTL1TBXAS1CFTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0865431-A2 COMPOUNDS Astra Pharmaceuticals Limited (GB) 1998-09-23 EP disclosed
WO-1997020815-A1 COMPOUNDS ASTRA PHARMACEUTICALS LTD. (GB) 1997-06-12 WO disclosed