Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 9/20 | 0.38 |
| ▸ | HTR1B | P28222 | 9/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552510 | 0.86 | DRD2 (0.40) | DRD2SLC6A4NPY5RHTR1DHTR1B | |
| SCHEMBL7478029 | 0.83 | HTR1D (0.58) | DRD2HTR1DHTR1B | |
| SCHEMBL8551514 | 0.82 | ALDH1A1 (0.42) | DRD2SLC6A4LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8551516 | 0.81 | DRD2 (0.40) | DRD2SLC6A4NPY5R | |
| SCHEMBL8551288 | 0.79 | HTR1D (0.40) | DRD2SLC6A4NPY5RLMNAMAPT | |
| SCHEMBL8550058 | 0.79 | DRD2 (0.41) | DRD2SLC6A4NPY5RHTR1DHTR1B | |
| SCHEMBL8552124 | 0.77 | DRD2 (0.43) | DRD2SLC6A4NPY5RLMNAMAPT | |
| SCHEMBL8547871 | 0.75 | HTR1D (0.43) | DRD2LMNAMAPTTDP1HTR1D | |
| SCHEMBL8704937 | 0.75 | DRD2 (0.44) | DRD2SLC6A4NPY5RLMNAMAPT | |
| SCHEMBL8547892 | 0.75 | HTR1D (0.46) | TDP1HTR1DHTR1BL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |