Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8704365 | 0.86 | DRD2 (0.42) | LMNAMAPTDRD2SLC6A4KMT2A | |
| SCHEMBL8548010 | 0.84 | DRD2 (0.40) | MAPTDRD2SLC6A4KMT2AMEN1 | |
| SCHEMBL8552297 | 0.83 | DRD2 (0.48) | DRD2SLC6A4 | |
| SCHEMBL8553071 | 0.82 | KMT2A (0.47) | LMNAMAPTKMT2AMEN1HSD17B10 | |
| SCHEMBL8553184 | 0.82 | RAB9A (0.41) | DRD2SLC6A4HTR1DHTR1B | |
| SCHEMBL8552355 | 0.82 | DRD2 (0.37) | MAPTDRD2SLC6A4KMT2AMEN1 | |
| SCHEMBL8552196 | 0.81 | HTR1D (0.34) | MAPTDRD2SLC6A4HTR1DHTR1B | |
| SCHEMBL8552356 | 0.80 | DRD2 (0.39) | DRD2SLC6A4 | |
| SCHEMBL8553522 | 0.80 | DRD2 (0.35) | MAPTDRD2SLC6A4KMT2ACYP2D6 | |
| SCHEMBL7489436 | 0.80 | HTR1D (0.60) | DRD2HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |