Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 5/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 7/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.40 |
| ▸ | EDNRA | P25101 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552362 | 0.91 | EDNRB (0.40) | EDNRBKEAP1NFE2L2EDNRAALOX5 | |
| SCHEMBL8551492 | 0.88 | ALOX5 (0.37) | EDNRBKEAP1NFE2L2EDNRAALDH1A1 | |
| SCHEMBL8553569 | 0.86 | EDNRB (0.54) | EDNRBKEAP1NFE2L2EDNRA | |
| SCHEMBL8591727 | 0.81 | EDNRB (0.56) | EDNRBEDNRAALDH1A1LMNA | |
| SCHEMBL8551968 | 0.81 | EDNRB (0.55) | EDNRBEDNRAALDH1A1LMNA | |
| SCHEMBL8550380 | 0.80 | EDNRB (0.41) | EDNRBKEAP1NFE2L2EDNRA | |
| SCHEMBL8548125 | 0.80 | EDNRB (0.45) | EDNRBEDNRA | |
| SCHEMBL8547944 | 0.79 | EDNRB (0.44) | EDNRBEDNRA | |
| SCHEMBL8551085 | 0.79 | EDNRB (0.45) | EDNRBKEAP1NFE2L2EDNRAALDH1A1 | |
| SCHEMBL8549027 | 0.78 | EDNRB (0.49) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |