Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 6/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.37 |
| ▸ | EDNRA | P25101 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PLEC | Q15149 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551492 | 0.92 | ALOX5 (0.37) | EDNRBKEAP1NFE2L2EDNRAALOX5 | |
| SCHEMBL8551351 | 0.91 | EDNRB (0.47) | EDNRBKEAP1NFE2L2EDNRAALOX5 | |
| SCHEMBL8550380 | 0.90 | EDNRB (0.41) | EDNRBKEAP1NFE2L2EDNRA | |
| SCHEMBL8550378 | 0.81 | EDNRB (0.51) | EDNRBEDNRATP53 | |
| SCHEMBL8548217 | 0.79 | EDNRB (0.51) | EDNRBEDNRAMAPTTP53 | |
| SCHEMBL8551944 | 0.79 | EDNRB (0.46) | EDNRBEDNRA | |
| SCHEMBL8553569 | 0.79 | EDNRB (0.54) | EDNRBKEAP1NFE2L2EDNRAMAPT | |
| SCHEMBL8548125 | 0.78 | EDNRB (0.45) | EDNRBEDNRAKMT2A | |
| SCHEMBL8553066 | 0.78 | EDNRB (0.43) | EDNRBEDNRAMAPTMEN1KMT2A | |
| SCHEMBL8551085 | 0.77 | EDNRB (0.45) | EDNRBKEAP1NFE2L2EDNRAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |