Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | EDNRB | P24530 | 8/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552362 | 0.92 | EDNRB (0.40) | ALOX5EDNRBKMT2AMEN1EDNRA | |
| SCHEMBL8551351 | 0.88 | EDNRB (0.47) | ALOX5EDNRBEDNRAKEAP1NFE2L2 | |
| SCHEMBL8550380 | 0.82 | EDNRB (0.41) | EDNRBEDNRAKEAP1NFE2L2 | |
| SCHEMBL8547683 | 0.79 | EDNRB (0.41) | EDNRBKMT2AMEN1EDNRA | |
| SCHEMBL8549138 | 0.78 | EDNRB (0.46) | EDNRBEDNRA | |
| SCHEMBL8548125 | 0.78 | EDNRB (0.45) | EDNRBKMT2AEDNRA | |
| SCHEMBL8551995 | 0.78 | EDNRB (0.41) | EDNRBEDNRA | |
| SCHEMBL8553569 | 0.76 | EDNRB (0.54) | EDNRBKMT2AEDNRAKEAP1NFE2L2 | |
| SCHEMBL8548588 | 0.75 | EDNRB (0.40) | EDNRBEDNRA | |
| SCHEMBL8547944 | 0.74 | EDNRB (0.44) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |