SCHEMBL8551451

SCHEMBL8551451

CCCCCCCCc1cnc(-c2ccc(-c3nc4ccc(CCCCCC)cc4s3)cc2)nc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 2/20 0.56
RAB9A P51151 7/20 0.53
KDM4E B2RXH2 5/20 0.53
MAPT P10636 5/20 0.53
GAA P10253 4/20 0.53
SMN1; SMN2 Q16637 4/20 0.53
ALDH1A1 P00352 2/20 0.53
HPGD P15428 2/20 0.53
MEN1 O00255 1/20 0.53
USP2 O75604 1/20 0.53
KMT2A Q03164 1/20 0.53
HSD17B10 Q99714 1/20 0.53
APP P05067 7/20 0.45
NPC1 O15118 5/20 0.44
NFKB1 P19838 2/20 0.44
NFKB2 Q00653 2/20 0.44
RELA Q04206 2/20 0.44
GLA P06280 2/20 0.44
STAT3 P40763 1/20 0.42
ATM Q13315 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9486227 0.93 RAB9A (0.53) RARBRAB9AKDM4EMAPTGAA
SCHEMBL8553099 0.90 APP (0.51) RARBRAB9AKDM4EMAPTGAA
SCHEMBL8554845 0.90 APP (0.51) RARBRAB9AKDM4EMAPTGAA
SCHEMBL5946763 0.90 APP (0.51) RARBRAB9AKDM4EMAPTGAA
SCHEMBL8551625 0.89 APP (0.50) RARBRAB9AKDM4EMAPTGAA
SCHEMBL5946928 0.86 CASP3 (0.46) RAB9AKDM4EMAPTGAASMN1; SMN2
SCHEMBL11335376 0.85 APP (0.63) RAB9AKDM4EMAPTGAASMN1; SMN2
SCHEMBL8554888 0.85 MAPT (0.56) RAB9AKDM4EMAPTGAASMN1; SMN2
SCHEMBL8218536 0.85 MAPT (0.56) RAB9AKDM4EMAPTGAASMN1; SMN2
SCHEMBL8371612 0.84 RARB (0.61) RARBRAB9AKDM4EMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0440061-B1 Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus CANON KK (JP) 1998-04-01 EP disclosed
US-5284599-A Benzothiazole with alkyl group having asymmetric carbon connected to halogen; improved response CANON KABUSHIKI KAISHA (JP) 1994-02-08 US disclosed
US-5236619-A Benzothiazoles CANON KABUSHIKI KAISHA (JP) 1993-08-17 US disclosed
EP-0440061-A1 Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus CANON KABUSHIKI KAISHA (JP) 1991-08-07 EP disclosed