Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8997236 | 0.79 | PTGS1 (0.39) | PTGS2PTGS1XDHKEAP1NFE2L2 | |
| SCHEMBL8997223 | 0.78 | XDH (0.46) | PTGS2PTGS1XDHKEAP1NFE2L2 | |
| SCHEMBL8997233 | 0.68 | PTGS1 (0.40) | PTGS2PTGS1XDHKEAP1NFE2L2 | |
| SCHEMBL8551424 | 0.67 | PTGS1 (0.65) | PTGS2PTGS1XDHGFER | |
| SCHEMBL10683662 | 0.66 | SMN1; SMN2 (0.47) | PTGS2PTGS1XDHGFERSMN1; SMN2 | |
| SCHEMBL60939 | 0.66 | KMT2A (0.71) | XDHRIPK2SMN1; SMN2 | |
| SCHEMBL8713644 | 0.66 | PTGS1 (0.49) | PTGS2PTGS1XDHGFER | |
| SCHEMBL174224 | 0.66 | KMT2A (0.62) | — | |
| SCHEMBL11005150 | 0.65 | KMT2A (0.49) | PTGS2SMN1; SMN2 | |
| SCHEMBL10770387 | 0.65 | SMN1; SMN2 (0.48) | PTGS2PTGS1XDHGFERSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885890-A1 | SULFONYLUREIDOPYRAZOLE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |