Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.39 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.39 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.39 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553916 | 0.92 | ADAMTS5 (0.48) | LTA4HEPHX2TRPV1ADAMTS5PLAAT3 | |
| SCHEMBL8552228 | 0.86 | HRH3 (0.37) | LTA4HEPHX2HRH3TRPV1ADAMTS5 | |
| SCHEMBL8552106 | 0.84 | TRPV1 (0.50) | EPHX2TRPV1KMT2A | |
| SCHEMBL27499495 | 0.82 | LMNA (0.48) | TRPV1TP53KMT2A | |
| SCHEMBL8554190 | 0.80 | TRPV1 (0.43) | TRPV1TP53KMT2A | |
| SCHEMBL27498888 | 0.79 | MAPT (0.47) | HRH3TP53MAPTKMT2A | |
| SCHEMBL8552214 | 0.78 | TRPV1 (0.42) | EPHX2TRPV1TP53KMT2A | |
| SCHEMBL8623812 | 0.77 | L3MBTL1 (0.39) | HRH3TP53MAPTKMT2A | |
| SCHEMBL8443114 | 0.75 | KMT2A (0.47) | KMT2A | |
| SCHEMBL8553467 | 0.75 | LMNA (0.48) | EPHX2TRPV1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | claimed |
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |