Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551594 | 0.86 | LTA4H (0.42) | HRH3LTA4HEPHX2KMT2ATP53 | |
| SCHEMBL8553916 | 0.84 | ADAMTS5 (0.48) | LTA4HEPHX2TP53MAPTADAMTS5 | |
| SCHEMBL8592027 | 0.80 | MAPT (0.40) | HRH3POLBKMT2AMEN1TP53 | |
| SCHEMBL8440371 | 0.77 | PLA2G7 (0.40) | POLBKMT2AMEN1TRPV1 | |
| SCHEMBL8552106 | 0.77 | TRPV1 (0.50) | EPHX2KMT2ATRPV1 | |
| SCHEMBL8442258 | 0.76 | TDP1 (0.34) | POLBKMT2AMEN1TRPV1 | |
| SCHEMBL27499495 | 0.75 | LMNA (0.48) | KMT2AMEN1TP53TRPV1 | |
| SCHEMBL8094854 | 0.73 | PLA2G7 (0.39) | KMT2AMEN1 | |
| SCHEMBL8554190 | 0.73 | TRPV1 (0.43) | POLBKMT2AMEN1TP53TRPV1 | |
| SCHEMBL8809869 | 0.72 | HRH3 (0.34) | HRH3POLBKMT2AMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | claimed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | claimed |
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |