Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.34 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550551 | 0.74 | HTR1B (0.41) | NOS1NOS3NOS2HTR1DHTR2C | |
| SCHEMBL8551471 | 0.73 | KCNH2 (0.35) | PARP1 | |
| SCHEMBL8551468 | 0.73 | KCNH2 (0.35) | PARP1 | |
| SCHEMBL5158843 | 0.73 | NOS1 (0.43) | NOS1NOS3NOS2SLC6A4 | |
| SCHEMBL8549330 | 0.72 | L3MBTL4 (0.45) | PARP1PTGS1PTGS2 | |
| SCHEMBL7484709 | 0.69 | PARP1 (0.39) | PARP1PTGS1PTGS2 | |
| SCHEMBL5160883 | 0.68 | NOS1 (0.42) | NOS1NOS3NOS2SLC6A4 | |
| SCHEMBL736186 | 0.68 | PARP1 (0.42) | PARP1 | |
| SCHEMBL14875929 | 0.66 | NOS1 (0.40) | NOS1NOS3NOS2SLC6A4 | |
| SCHEMBL9050184 | 0.66 | PARP1 (0.39) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736025-B1 | DYHYDROBENZOFURANYL-BIPHENYL CARBOXAMIDES HAVING 5HT1D ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-07-22 | — | — | EP | disclosed |
| US-5700818-A | Dihydrobenzofuranyl-biphenyl carboxamides having 5HT1D antagonistic activity | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-12-23 | — | — | US | disclosed |
| EP-0736025-A1 | DYHYDROBENZOFURANYL-BIPHENYL CARBOXAMIDES HAVING 5HT 1D? ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995017401-A1 | DYHYDROBENZOFURANYL-BIPHENYL CARBOXAMIDES HAVING 5HT1D ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-06-29 | — | — | WO | disclosed |