Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.47 |
| ▸ | HTR2A | P28223 | 9/20 | 0.47 |
| ▸ | DRD3 | P35462 | 9/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552345 | 0.83 | DRD2 (0.54) | DRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8547778 | 0.82 | DRD2 (0.41) | DRD2HTR2ADRD3MAPTSLC6A4 | |
| SCHEMBL8547782 | 0.80 | DRD2 (0.41) | DRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8549862 | 0.80 | DRD2 (0.38) | DRD2HTR2ADRD3MTNR1AMTNR1B | |
| SCHEMBL7489436 | 0.80 | HTR1D (0.60) | DRD2 | |
| SCHEMBL8552293 | 0.80 | LMNA (0.42) | DRD2LMNAMAPTSLC6A4MEN1 | |
| SCHEMBL8550072 | 0.77 | MAPT (0.44) | DRD2HTR2ADRD3LMNAMAPT | |
| SCHEMBL8704542 | 0.77 | ALDH1A1 (0.53) | DRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8548389 | 0.75 | DRD2 (0.39) | DRD2HTR2ADRD3MTNR1AMTNR1B | |
| SCHEMBL8548755 | 0.74 | CA2 (0.43) | DRD2HTR2ADRD3MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |